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The gut microbiota depletion model using antibiotic treatment in HFD-fed mice revealed that gut microbiota and their dietary fatty acid-derived metabolites are crucial in nicotine-induced body weight loss

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Although there were other differences, such as darkening of lower lids, wrinkles across the forehead, frown lines, crows feet and lines on the lower lips with accentuated puckering, none of these showed a statistically significant difference between the smokers and non-smokers evaluations