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Timing-dependent effects primarily influence circadian phase alignment, sleepwake timing, and synchronization between central and peripheral clocks, whereas dose-dependent effects are more closely related to signal amplitude, antioxidant capacity, and cytoprotective actions

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Biochem Biophys Res Commun 209:227233 Mulcahy RT, Untawale S, Gipp JJ (1994) Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells