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4850 Traditional mechanisms of gallbladder disease development Gallbladder diseases, in particular cholelithiasis, are usually due to alterations in bile composition, gallbladder motility, or bile flow regulation

Some pointed to evidence suggesting that not everyone diagnosed with obesity needs to lose weight to stay healthy and bemoaned the use of BMI, a controversial measure that is increasingly considered inadequate unless additional factors such as waist circumference are also evaluated

Discrepancies between analyses employing genetic instruments and actual phenotypes may provide intriguing insights on relevant dynamics

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