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Although the TyG index and METS-IR were significantly correlated with circulating MOTS-c in univariate analysis, these associations disappeared in multivariate model, indicating that BMI and HOMA-IR better represent the metabolic condition underlying MOTS-c regulation

Jacoby, J.C

10.1186/s12986-015-0044-z 56 GumeniS.PapanagnouE

Previous studies have shown a positive association between blood levels of 25(OH)VD and GSH in healthy adults and diabetic patients 8,19

These findings suggest that metformin has anti-seizure activity by activating AMPK signaling and inhibiting mTOR pathways which are dysregulated in epilepsy