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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 15% by weight of the viscosity modulating agent(s)

Given that the gut-host interaction is necessary for the maintenance of normal host physiological functions and the considerable evidence implying its role in the pathogenesis of a myriad of diseases including CVD 9 , we sought to provide a mechanism by which dysregulated gut homeostasis due to BoCA consumption could drive cardiovascular dysfunction

The homodimeric enzymes display a conserved structural fold