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However, even though some bacteria of the microbiota residing in the large intestine produce Cbl, mammals are not able to uptake Cbl produced at this location, since the site of B12 absorption is located in the small intestine

and one published human clinical study examining intra-articular injection in 12 patients with chronic knee pain, of whom 7 out of 12 reported relief lasting over 6 months [15]

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