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Herein, we present a cross-sectional study on a cohort of 75 cEDS patients from 44 families with a confirmed molecular diagnosis focusing on the diagnostic criteria recognized in the current EDS nosology and on additional mucocutaneous, osteoarticular, musculoskeletal, cardiovascular, gastrointestinal, uro-gynecological, neuropsychiatric, atopic, and facial/ocular features, in order to investigate the multisystemic involvement and natural history of the disorder

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Emmerich said the film would deal with Smith's character in a"very respectful way" while keeping him "still part of this universe." "In the very beginning, I wanted to work with him and he was excited to be in it but then after a while he was tired of sequels, and he did another science fiction film, which was his father-son story, so he opted out," Emmerich dished

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