Meet the experts: Austin Shuxiao, MD, is an internal medicine physician and the founder and medical director of PeachIV, a New York City-based company for home IV treatments
Fortunately, its possible to reverse this condition in many people, especially with support from a qualified functional medicine provider
To truly understand how glutathione operates, one must look at the continuous biochemical loop known as the redox (reduction-oxidation) cycle
Comparative Antioxidant Profiles Property Glutathione (GSH) Ergothioneine (EGT) Redox activity Very high, dynamic Moderate, stable Chemical stability Low (constantly recycled) Very high Specific transporter No Yes (OCTN1/SLC22A4) Tissue accumulation Limited High (brain, liver, eyes) Mitochondrial protection Indirect (via GPx) Direct DNA protection Mitochondrial (primary) Nuclear and mitochondrial Intestinal degradation Partial Very low Human synthesis Yes (liver) No (dietary only) Mushrooms as the Only Known Source of Both Molecules While glutathione is also found in other foods asparagus, avocado, red meat ergothioneine is found almost exclusively in mushrooms
ACS Omega (2020) 5:2546775