These substances are formed during our normal metabolism
J Membr Biol 69:112 Mulcahy RT, Bailey HH, Gipp JJ (1995) Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan
Glutathione Supplementation Summary Oral powder (not recommended) Liposomal glutathione formulation (recommended) Inhaled GSH with a special nebulizer (recommended but need a prescription) Transdermal and lotions (variable levels of absorption) IV (most effective but also most invasive) Boost levels with selenium, ALA, NAC, and/or SAMe (recommended) Glutathione supplementation has a few rare side effects, including abdominal cramps, bloating, loose stools, gas, and possible allergic reactions such as rash
Understanding what science actually supports helps set realistic expectations for either supplement
Hornstra G Journal article: CLINICAL NUTRITION