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Moreover, chronic hyperglycemia causes NG2-glia to take up more glucose and release more lactate

This mechanism is different from acid-suppressing drugs like proton pump inhibitors (PPIs) or H2 blockers, which reduce acid production but do not affect the LES function directly

The higher expression of H19 will then inhibit telomerase activity in cancer cells (without affecting hTERT expression), thereby allowing ALT to continue telomere maintenance