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Studies on protein therapeutics consistently show that agitation-induced degradation is one of the primary causes of potency loss

in particular, the relative abundance of Bifidobacterium adolescentis, Alistipes onderdonkii, and Eubacterium rectale was positively correlated with IL-6, high sensitivity C-reactive protein (Hs-CRP) and LPS-binding protein (LBP), while the abundance of Bacteroides thetaiotaomicron was correlated with LBP levels [55]

The frequency of self-reported side effects was compared between antioxidant and placebo groups, and categorized by seriousness