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Despite concerns about the potential increased risk of thyroid cancer, semaglutides overall cancer risk profile is favorable, with benefits generally outweighing risks

However, the drug was subsequently overtaken by Pfizers Lipitor (FDA-approved in 1996), which generated ~$100B in sales from 1992 to 2017

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It builds on a foundation that will enable us to devise treatment algorithms combining surgery and medicine for more severe forms of obesity