These modifications include an Ala8Aib amino acid substitution and attachment of a C18 fatty diacid side chain at Lys26 via a linker that promotes albumin binding, significantly prolonging circulation time compared to native GLP-1
Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limn P, Ren X, Lam TT, Schwartz GJ, de Araujo IE
A significant focus was on developing inhibitors of insulin-regulated aminopeptidase (IRAP), a protein identified as the AT4 receptor, with the goal of enhancing metabolic stability and BBB permeability
Int J Obes Suppl 6 , S15S21, (2016)
And for general peptide research context , our comprehensive resource library provides evidence-based information across all major peptide categories