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Indian J Cancer 47(1):5358 Pacifico A, Goldberg LH, Peris K, Chimenti S, Leone G, Ananthaswamy HN (2008) Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers.[Erratum appears in Br J Dermatol
Ramos-Alvarez I, Moreno P, Mantey SA, Nakamura T, Nuche-Berenguer B, Moody TW, Coy DH, Jensen RT
The adiponectin gene is located on chromosome 3q26, a region highly susceptible to the development of metabolic syndrome and Type 2 diabetes mellitus. Research conducted on the Pima Indians of Arizona, a population with the highest known prevalence of Type 2 diabetes, has shown low adiponectin levels are associated with insulin resistance, whereas higher concentration of adiponectin helped protect against development of Type 2 diabetes. CNIs in addition to increasing insulin resistance, induces pancreatic beta cell apoptosis if administered in large doses., resulting in decreased insulin secretion. Thus CNIs, while effective in preventing organ rejection, disrupt glucose metabolism by increasing insulin resistance and reducing insulin secretion leading to abnormalities in the glucose homeostasis (Figure 1)
