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Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)

One limitation is that effective penetrating concentrations of CPPs are generally above micromolar and these concentrations are difficult for CPPs in vivo due to instability (Milletti, 2012

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Prior to the development of these targeted compounds, metabolic and longevity research relied largely on indirect calorie restriction models or broad hormonal modulation

[DOI] [PubMed] [Google Scholar] 5.Lower EE, Weiss KL