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We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)

Handzlik MK, Metallo CM

USA 86 , 14111415 (1989) Trussell, L

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That work helped set the stage for the current study, which examines the complex links between antioxidants, metabolism, and cancer