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Methodology & quality box Synthesis & fill: EU laboratory standard, sealed vials, dose-validated per unit Identity: HPLC purity + MS confirmation, per lot Endotoxin: LAL result in EU/mg on lot CoA Traceability: lot number on vial maps to synthesis record, analytical files and shipping batch CoA access: issued per lot, available on request before dispatch Status: research use only

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A weight reduction of 15% or more at 13 weeks was achieved by 31.2% of those receiving 10 mg VK2735 and 41.5% of adults receiving the 15 mg dose