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Herrero M, del Pilar S-C, Cifuentes A, Ibez E (2015) Plants, seaweeds, microalgae and food by-products as natural sources of functional ingredients obtained using pressurized liquid extraction and supercritical fluid extraction

3.2.3.2 Caffeic acid phenethyl ester (CAPE) CAPE, a natural antioxidant, possesses beneficial roles in cadioprotective, neuroprotective and renoprotective effects ( 3.2.3.3 Astaxanthin Astaxanthin, a natural non-toxic product in most of marine organisms, exhibits wide biologic properties, such as strong antioxidant, anti-apoptotic and anti-inflammatory activities, for its unique structure ( via its antioxidant activities in several kidney diseases, such as DKD ( 3.3 Promoting mitophagy Mitophagy is a specialized form of autophagy

A gradual increase in drug dosage over time has been shown to reduce these side effects

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In addition, prolonged strain on the liver has been reported, with some cases showing abnormal enzyme levels that affect overall health