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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]

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28 In addition, Decaisnea insignis seed oil mitigated liver dysfunction in L-carnitine-fed mice, potentially by modulating the composition of the gut microbiota, reducing the abundance of Firmicutes, Proteobacteria, and Erysipelotrichaceae, as well as the proportions of Lactobacillus and Akkermansia, thereby preventing TMAO generation