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Psoriasis disease and medical history characteristics included psoriasis disease duration, history of psoriasis in a difficult-to-treat area (scalp, genitals, nails, palms and soles, or inverse/intertriginous areas), history of non-plaque psoriasis (guttate, erythrodermic, or pustular), and the number of previous topical therapies used (corticosteroids, tacrolimus, pimecrolimus, calcipotriene/calcitriol, vitamin D 3 analogue/steroid combination, tar, anthralin, tazarotene, roflumilast, or tapinarof)

A particularly compelling mechanistic extension is the proposed formation of a proteoglycan/glycosaminoglycan (GAG)-rich interface after VUV photofunctionalization, supported by (i) enrichment of heparin-/GAG-/sulfur-compoundbinding gene clusters and (ii) loss-of-function attenuation of the adhesion advantage using GAG-degrading enzymes [125]

2016;150:734-57 Julsgaard M, Christensen LA, Gibson PR, Gearry RB, Fallingborg J, Hvas CL, Bibby BM, Uldbjerg N, Connell WR, Rosella O, Grosen A, Brown SJ, Kjeldsen J, Wildt S, Svenningsen L, Sparrow MP, Walsh A, Connor SJ, Radford-Smith G, Lawrance IC, Andrews JM, Ellard K, Bell SJ

The bottom 2.5 percent and the top 2.5 percent values are considered abnormal

While some of those reports describe meaningful before and after results , anecdotal evidence cannot control for placebo effects, concurrent lifestyle changes, or variations in formulation quality between different compounding pharmacies