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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

This standard protocol typically begins with a low initiation dose (e.g., 0.25 mg once weekly) and gradually increases over several weeks or months to a maintenance dose, depending on individual tolerability and treatment goals

Non-solubilized folic acid in dry materials is not sensitive to irradiation treatment, while it is easily degraded in aqueous solutions 348,349

Cell Rep 29(10):32353252e3239 Gao B, Wu Y, Yang Y-J, Li W-Z, Dong K, Zhou J, Yin Y-Y, Huang D-K, Wu W-N (2018) Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

References Li H, Guo A, Wang H (2008) Mechanisms of oxidative browning of wine