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The Research Shift: New Evidence for Oral Use While the skepticism around oral glutathione was once the standard view, modern research has begun to change the conversation

A 2021 trial in *New England Journal of Medicine* found that participants on 2.4 mg lost approximately 15% of body weight over 68 weeks, compared to 10% at 1.7 mg, suggesting that additional benefit existsbut it's modest for many individuals

Berberine may support 1.5-2 kg of weight loss over several months, compared to 12-15 kg with GLP-1 medications

GSH protects endothelial cells by neutralizing ROS and sustaining NO levels

Additionally, a co-culture system of MCECs and MPMs revealed that GHK-Cu facilitated MCECs healing, impaired by DSS, by upregulating ZO-1 and Occludin expression