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Contrary to GLP-1R mono-agonist, whose efficacy is limited by dose-dependent gastrointestinal events, the new triple agonists can simultaneously increase energy expenditure, reduce food intake, and improve glucose control by engaging all three receptors at once

However, as recently reviewed, the role of OCTN2 in breast cancer, either ER+ or ER-, is not straightforward when considering prognosis and patient survival after cancer treatment

Walker and Huberman dissect the repercussions of ignoring these elements, touching on the significance of aligning one's sleep habits with their natural chronotype for optimal health

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