Afferent fibers from the trigeminal ganglion synapse on neurons in the trigeminal cervical complex (2), and ascending pathways transmit signals to various brain regions, causing pain, cutaneous allodynia, and sensory disturbances like photophobia and phonophobia (6, 34)
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The conservation of the NOPPP among archaea suggests an ancient evolutionary origin of the NOPPP, while the OPPP seems to arise more recent in evolution