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Michael Gapen: I think the right thing to do Again, our job is to say what we think he will do not what he should do

Clinical studies show tirzepatide provides superior A1C reduction (up to 2.4% decrease) and weight loss compared to semaglutide, but requires careful monitoring for hypoglycemia, especially in patients on insulin or sulfonylureas

As clinicians increasingly prescribe these agents for glycemic control and cardiovascular benefit, the need for clarity around rhythm outcomes continues to grow

We talk to a patient who says it helped and experts about the risks and the unknowns

In most clinical settings, the peptide is studied via small subcutaneous injections, usually administered in the morning on an empty stomach to maximize the fat-burning signal