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Results Administration of exogenous melatonin alleviates allergic airways disease severity in allergen-exposed mice Given the growing evidence linking circadian disruption to increased severity of allergic asthma ( Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously (31) ( Figure 1A )

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Mice carrying the dominant-negative Clock mutation develop obesity, hypertriglyceridemia, and marked hepatic steatosis driven by persistent activation of SREBP-1cmediated lipogenesis (40)