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Adequate levels of B12 maximise the uptake of folate

The PI3K/Akt pathway cooperates with cAMP/PKA to mediate -cell survival, improve insulin sensitivity in muscle and adipose tissues, reduce oxidative stress, and protect vascular endothelial function [36, 37]

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Different manipulations affecting glutamate homeostasis were reported to induce compromised performance in hippocampus-dependent spatial acquisition tasks [51, 52] and mPFC-dependent reversal assays [53,54,55]

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