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Specifically, AGK-2 significantly inhibits the SIRT2 expression and the interaction of SIRT2 with FoxO3a to reduce the deacetylation of FoxO3a and nuclear translocation and decreases the Fas Ligand (FasL) expression and the activation of caspase-8 and caspase-3 (Wang et al., 2017)
The platelets have natural affinity to adhere to injured endothelial cells and thrombogenic matrix on plaques, thereby promoting their targeted binding to the plaque surface