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MR-PRESSO identified outliers for autism and major depression, but no global pleiotropy was detected for other outcomes (Supplementary Table S5)

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For the extraction of mRNA, tissue samples were homogenized in TRI Reagent (Molecular Research Center) using a TissueLyser II system (Qiagen) and then chloroform extracted, precipitated using isopropanol, washed with 75% ethanol, and reconstituted with DEPC-treated water