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For most people, the first noticeable effect is a reduced appetite

Helpful strategies may include: Regular physical activity Consistent sleep routines Stress reduction techniques Mindfulness practices Relaxation exercises Healthy nutrition Limiting caffeine and alcohol Building supportive relationships While lifestyle changes alone may not eliminate anxiety, they can significantly support long-term recovery

In the SURMOUNT-5 head-to-head trial against semaglutide, tirzepatide at maximum dose produced 20.2% weight loss compared to semaglutide at 13.7%

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