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Until now, very little large-scale or FDA-approved work has been conducted on marijuana because its classified as a Schedule 1 illegal drug. But theres hope that research will go forward: An article published in the February 2016 issue of JAMA Psychiatry urges, We should try to learn as much and as rapidly as we can from the ongoing changes in local policies to minimize the harms and maximize the potential benefits. THC the active ingredient in marijuana is a highly protein binding substance, meaning it attaches to plasma proteins in the blood