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Shortterm results of a randomized, doubleblind, sham controlled study

Previous studies have also determined that AM404 prevents the activation of transcription factors NFAT and NF-B but preserves extracellular signal-regulated kinases (ERK)1/2 MAPK signaling in vivo [30,67]

A crucial role of lactate accumulation in cancer cells has been demonstrated regarding its ability to induce expression of anti-inflammatory and proangiogenic genes, together with the modification of histones through a process called lactylation, where a lactyl-CoA is added to lysine residues present in the tails of histones [33]

Vitamin E seals everything in