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DSIP administration has been reported in rodent models to attenuate stress-induced elevations of ACTH and corticosterone and to modify behavioral responses to acute stressors (Graf & Kastin, 1984)

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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard