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10.1016/S0887-8994(97)00026-X Matsumoto J, Ogawa H, Maeyama R, Okudaira K, Shinka T, Kuhara T, Matsumoto I: Successful treatment by direct hemop-erfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication

This insulin resistance slows the metabolism of sugar in the cells, leading to their accumulation in the blood causing hyperglycemia

However, because of its calming effects on the brain, it may be prescribed off-label (for a purpose not officially authorized by the FDA) for weight loss, alcohol use disorder, bipolar disorder, post-traumatic stress disorder (PTSD), and even eating disorders like binge eating disorder and bulimia

This is the most important theoretical risk of this specific stack

Proline metabolism and cancer