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Using human hippocampal samples and mouse neuronal cells, one study discovered that GSK3B inhibition led PI3Ks to induce xCT, which is essential for the modulation of oxidative stress resistance of nerve cells by the PI3Ks

P.BetarbetR.TaylorG.ChengD.et al

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Other studies reported lactic acidosis and increased alanine levels, it is highly recognized that high concentrations of lactate can inhibit mitochondrial respiration and disbalance the redox equilibrium (Oliveira et al., 2005)