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The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties, says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial

Food and Drug Administration (FDA) issued a final ruling stating that aloe and cascara sagrada cannot be labeled or sold as stimulant laxatives in over-the-counter (OTC) drug products due to a lack of research on safety and efficacy

In rare reports this can have serious or fatal outcomes * seek urgent medical attention if you experience severe, persistent abdominal pain, that may radiate to your back and may be accompanied by nausea and vomiting, as this may be a sign of pancreatitis * do not restart GLP-1 receptor agonist or GLP-1/GIP receptor agonist treatment if pancreatitis is confirmed * report suspected side effects through the Yellow Card scheme

All subsequent steps were performed in the dark