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Two phase II trials - one in a population with obesity (without T2D) [45], and a second in a population with T2D and overweight/obesity [46], have recently been published and their key findings are presented below (Table 1)

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(33896531) Phenytoin accumulation, as well as an increased free fraction of phenytoin, may tend to cause phenytoin toxicity

Research examines downstream signaling and metabolic-pathway responses rather than a confirmed receptor interaction