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Agents Linaclotide [5] Peptide agonist of guanylate cyclase-C Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Lubiprostone [5] Prostaglandin derivative that activates chloride channels on the apical surfaces of enterocytes Increases intestinal fluid secretion and improves fecal transit Plecanatide [22] A guanylate cyclase-C agonist Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Adverse effects Special patient groups Constipation in infants, children, and adolescents is detailed separately

Clayman : It was patient driven

A double-blind, randomized, placebo-controlled trial

Made from three amino acids, glutamine, cysteine, and glycine, glutathione plays a crucial role in protecting cells from damage and supporting your bodys detoxification processes

The goal is finding the right balance that preserves your vision while maintaining your broader health benefits