At the cellular level, activation of beta-2 receptors produces bronchodilation through multiple pathways, most of which involve stimulation of adenylyl cyclase and phosphorylation of target proteins by protein kinase A (PKA)
10.3181/00379727-190-42879 Proc
doi:10.1006/bbrc.1999.1403 Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C, Joshi-Barve S (2012) Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress
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In a recent study, it was shown that patients with asthma who were well controlled with inhaled corticosteroids and long-acting 2 agonists had higher lipid peroxide levels compared with healthy controls [113]
