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doi:10.3390/biomedicines6030091 Patel KR, Scott E, Brown VA, GescherAJ, Steward WP, Brown K

Glutathione Biology: Primary cellular antioxidant made from cysteine, glycine, and glutamate

Given that IGF can bypass IGF-IR to activate alternative signaling pathways, the stroma-derived IGF may contribute to resistance to anti-IGF-IR agents