It has a high affinity for -receptors, which helps reduce cravings and withdrawal symptoms in individuals with opioid dependence (91)
However, if youre targeting more specific outcomes, like nerve repair or enhanced cognitive function, you might need a higher dosage, possibly up to 1,500 mg per day
Garg R, Schuman B, Bader A, Hurwitz S, Turchin A, Underwood P, et al
Metformin therapy and cognitive dysfunction in patients with type 2 diabetes: a meta-analysis and systematic review
Whether a symptom you are experiencing is expected, whether it warrants a change in plan, and what to do about it are clinical judgments that depend on your other medications, your history and your examination