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At the molecular level, IL-4 and IL-13 bind to their receptors on the cell surface, activating the JAK1/STAT6 signaling pathway, which in turn upregulates the expression of key regulatory molecules such as PPAR and SOCS, thereby promoting the polarization of microglia toward the M2 phenotype (44, 45)

Holothurian glycosaminoglycan from Apostichopus japonicus (AHG) can suppress hepatic glucose production for the development of an anti-hyperglycemic agent