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If it doesnt make it to the mitochondrial matrix, the fat will not get burned, even if you are following a strict diet or exercise regularly

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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

Chronic Exposure to Dioxin-Like Compounds and Thyroid Function Among New York Anglers

doi:10.1128/msystems.00001-18 88