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Meanwhile, orforglipron has shown latestage evidence supporting use as weightloss maintenance after injectables , a realistic longterm strategy once approved

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El-Sayed has built his campaign around bold policy proposals, rejecting corporate PAC money and casting himself as an alternative to the status quo of the Democratic Party

Danuglipron, developed by Pfizer, showed 813% placebo-adjusted weight loss in Phase IIb studies, though high discontinuation rates highlight ongoing challenges with GI tolerability and formulation [87, 88]