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doi: 10.3389/fphar.2023.1063033 Received 06 October 2022 Accepted 17 March 2023 Published 30 March 2023 Volume 14 - 2023 Edited by Mark M

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Redness over an involved joint (gout is highly inflammatory) Involvement of the base of the big toe on one side (the most common site for gout) Involvement of the joints at the middle of the foot Uric acid elevation on blood testing X-ray findings of swelling of joints which is not symmetrical Joint fluid is tested for infection and is negative

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Supplementation: Glutathione supplements (in liposomal or reduced forms for better absorption) can provide a direct increase in glutathione levels in the body