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The second is the eligibility threshold BMI 30 versus BMI 27 with comorbidity

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Importantly, pharmacokinetic analyses have demonstrated no significant differences in tirzepatide metabolism among healthy individuals, patients with renal impairment,186 or those with hepatic dysfunction,187 obviating the need for dose adjustments in these populations.61 Phase II clinical trials first evaluated tirzepatide in T2DM patients managed with lifestyle modifications alone or in combination with metformin

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