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Their activity is regulated by various factors, including the RANKL-RANK-OPG signaling pathway, estradiol, various cytokines and calciotropic hormones ( Cigarette smoking creates an imbalance in bone turnover, which leads to lower bone mass and decreased bone mineral density and makes bones prone to osteoporosis and fractures
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The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to pml oncogenic domains
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