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The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma

This complex molecular network highlights GCs heterogeneity and underscores the need to integrate mechanisms like molecular subtyping, metabolic regulation, and epigenetic modifications to develop novel therapies and combination strategies, ultimately advancing individualized precision medicine

In laboratory settings, DSIP is applied in biochemical assays, EEG-based sleep studies, and preclinical models to explore how peptide signaling influences central nervous system function and stress-response mechanisms

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