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There is a lot of variance in gene expression levels, even for identical genes in different individuals [44-46]

S.SainiM.PandyaU.AwasthiS.et al (2001)

Thus, convincing experimental evidence obtained from invertebrates and nonhuman vertebrates taught us that down-regulated IIS is of critical importance for metabolic homeostasis, improved oxidative stress responses and longevity

4 Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growthfactor-1 resulting in elevated sustainable insulin-like growth factor binding protein 3 plasma levels. National Center for Biotechnology Information