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Air pollution also contains polycyclic aromatic hydrocarbons (PAHs) which have been associated with a number of cancers including cancers of the lung and breast (459)Shen J, et al

This ties back to reinforcement

There are some reviews that performed the quality assessment of included studies but had uncertainty about inclusion of all relevant studies 23,30

Its leaves contain high levels of the addictive chemical nicotine which is harmful to health and causes adverse effects

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